People from all over the world trust their hearts to the Smidt Heart Institute at Cedars‑Sinai
The Smidt Heart Institute has received worldwide acclaim for consistently achieving the best outcomes for people with heart disease. Working seamlessly with clinicians, our investigators break new ground with lifesaving research efforts that effect change in California and around the globe.
393
Active clinical trials in 2023
$45M+
Over $45 million in total research funding in 2023
582
Peer-reviewed articles published in 2023
Latest Research
Cardiac Surgery
The Future Direction of Post‑Transcatheter Aortic Valve Replacement Re-Interventions: Insights From the Society of Thoracic Surgeons National Database.
Annals of Cardiothoracic Surgery
Cardiac Surgery
Chronic Extraction of Stylet‑Driven Leads Implanted at the Left Bundle Branch Area in a Preclinical Model.
Heart Rhythm
Cardiac Surgery
Racial and Gender Disparities in the Management and Outcomes of Patients With Acute Mesenteric Ischemia: A Nationwide Retrospective Cohort Analysis.
The Journal of Surgical Research
Cardiac Surgery
The Current State of Redo Transcatheter Aortic Valve Replacement (TAVR) and Limitations: Why TAVR Explant Is Important as the Valve Reintervention Strategy.
Annals of Cardiothoracic Surgery
Cardiology
Pulsed Field Ablation for Persistent Atrial Fibrillation: 1‑Year Results of ADVANTAGE AF.
Journal of the American College of Cardiology
Cardiology
Impact of Climate Change and the Environment on Cardiovascular Health and Role of Healthcare.
American Heart Journal Plus: Cardiology Research and Practice
Cardiology
Pulsed Field Ablation of Persistent Atrial Fibrillation With Continuous ECG Monitoring Follow‑Up: ADVANTAGE AF-Phase 2.
Circulation
Cardiology
Temporal Trends in Transcatheter Aortic Valve Replacement Outcomes in Patients With Low‑Flow, Low-Gradient Aortic Stenosis: Insights from The TOPAS -TAVI Registry.
The Canadian Journal of Cardiology
Cardiology
Healthcare Expenditure on Atrial Fibrillation in the United States: The Medical Expenditure Panel Survey 2016 to 2021.
JACC. Advances
What if a stent could grow as a patient ages?
Investigators at the Smidt Heart Institute continue to lead research endeavors to improve survival and outcomes for heart transplant patients and make transplant successful for the sickest patients.
1,600+
Heart Transplants to Date
Leadership & Faculty
Research Initiatives
Advanced heart disease and transplantation
Artificial intelligence
Cardiac imaging
Cardiogenetics
Cardio‑Oncology
Congenital heart disease
Healthy aging
Hypertension
Interventional Cardiology—Structural and Coronary Interventions
Myocardial biology
Novel therapeutics
Preventive cardiology
Proteomics
Rhythm disorders
Vascular biology
Women’s heart health
Research Programs
With state-of-the-art facilities, we advance cardiovascular research. Our collaborators contribute to groundbreaking studies aimed at improving patient care.
Laboratories
Centers & Divisions
Departments & Institutes
Cores
Educational Programs
Cedars-Sinai is a global hub for medical research and training, attracting top physician-scientists to foster invention and teamwork.
Fellowships
Residencies
Other Educational Opportunities
Heart Clinical Trials

Leading the way in clinical trials and investigational devices, the collaborative team at the Smidt Heart Institute at Cedars‑Sinai is reimagining cardiac care.
More From Smidt Heart Institute
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